Wigan Athletic man explains Blackburn Rovers switch
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The summer signing has plenty of experience of this fixture, but this will be his first time on the 'right' side.
"I played against Wigan a few times for Blackburn, in the Championship and also a couple of times in League One," he said.
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Hide Ad"They were always interesting games, especially the ones in League One when both teams were going for the title."
Some eyebrows were raised earlier this summer - mostly in East Lancashire - when, after turning down a new deal at Ewood, Nyambe joined Latics.
The player, though, insists it wasn’t a decision he took lightly.
"It's something I had in the back of my mind for some time, to be fair," Nyambe revealed.
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Hide Ad"I think I needed to step out of my comfort zone, and see what was out there.
"I just needed a fresh start, a new challenge, to kick on and progress with my career.
"I had a lot going on towards the end of last season, we had a baby on the way, and I needed to make sure it was the right move.
"It was important to not be too far away from home, not having to travel too far, so coming here was a big plus.
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Hide Ad“I'm from Manchester, which is only just down the road, so it's perfect.
"I sat down with the manager and his staff, and I just felt they were the right people to bring my game on.
"I knew a couple of the players already, who have improved here, and I wanted that for myself."
Nyambe also wasn't daunted by the presence of skipper Tendayi Darikwa in his right-back position.
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Hide AdAnd after working his way to full fitness following a condensed pre-season, Nyambe has started the last two games after Darikwa dislocated a shoulder against Burnley.
"People need to understand in football that it's a squad game, and everyone needs competition for places," he added.
"It's difficult for anyone to challenge themselves when there isn't that at a club.
"Someone challenging for your place isn't a bad thing, it will benefit you and the club in the long haul."